发明名称 |
COMPOSITIONS AND METHODS FOR PERSONALIZED NEOPLASIA VACCINES |
摘要 |
The invention provides a method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, which includes identifying a plurality of mutations in the neoplasia, analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof, and producing, based on the identified subset, a personalized neoplasia vaccine. |
申请公布号 |
WO2014168874(A3) |
申请公布日期 |
2014.12.18 |
申请号 |
WO2014US33185 |
申请日期 |
2014.04.07 |
申请人 |
THE BROAD INSTITUTE, INC.;DANA-FARBER CANCER INSTITUTE, INC.;THE GENERAL HOSPITAL CORPORATION |
发明人 |
HACOHEN, NIR;WU, CATHERINE, J.;FRITSCH, EDWARD, F. |
分类号 |
A61K39/00;A61P35/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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