| 摘要 |
<p>The present invention discloses the preparation method of drospirenone. 3²,5-dyhydroxy-6²,7²,15², 16²-dimethylene- 5²-androstane-17,20-epoxy is taken as the raw material. It is subject to oxidization of the hydroxyl at the 3 rd position, ketalization of 3-ketone group, condensation reaction and deesterification to obtain carboxylic acid lactone, sulfonation of the hydroxyl at the 5 th position, and deketalization and desulphonation in the reaction system of glacial acetic acid and sodium acetate to produce the 3-keto-4-alkenyl compound, thus obtaining drospirenone. The preparation method of the invention has high intensification, reaction specificity, less by-products and high yield of products in each step, thus overcoming the disadvantages of low yield and unstable quality.</p> |
