发明名称 |
HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 |
摘要 |
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that at least one of R 1 and R 2 is hydroxy; R 3 is selected from hydrogen; halogen; cyano; optionally substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is selected from hydrogen; a group -(O) n -R 7 where n is 0 or 1 and R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C 1-5 hydrocarbylamino; or R 3 and R 4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR 5 R 6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors. |
申请公布号 |
PT2332909(E) |
申请公布日期 |
2014.12.17 |
申请号 |
PT20110158930T |
申请日期 |
2006.04.13 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
ROBERT DOWNHAM;MARIA GRAZIA CARR;ANDREW JAMES WOODHEAD;MARTYN FREDERICKSON;GIANNI CHESSARI;MILES STUART CONGREVE;EVA FIGUEROA NAVARRO;CHRISTOPHER MURRAY;MICHAEL ALISTAIR O'BRIEN;THERESA RACHEL PHILLIPS;ALISON JO-ANN WOOLFORD |
分类号 |
C07D209/44;A61K31/403;A61K31/438;A61K31/439;C07D209/08;C07D215/08;C07D401/04;C07D401/12;C07D471/04;C07D471/10;C07D491/08;C07D491/10 |
主分类号 |
C07D209/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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