Method of a pharmaceutical delivery system for use within a joint

摘要

Methods and apparatus of providing a joint replacement parts with a pharmaceutical delivery system is provided. The pharmaceutical delivery system is placed within the joint replacement parts to provide, over a period of time, sustained release of a controlled concentration of pharmaceuticals within the joint space of the joint replacement and to produce a local or systemic physiological of pharmacological effect.

主权项

1. A drug delivery system for the sustained administration of a pharmaceutical into a joint replacement at a controlled rate to produce a beneficial response, said device comprising:
a. a plurality of bodies comprising at least one portion of pharmaceutical composition mixed with at least one portion of polymer composition; b. a joint replacement having multiple inserts wherein said inserts are drilled to cause a plurality of openings to accommodate said plurality of bodies; c. wherein said plurality of bodies are placed inside said plurality of openings without interfering with said joint replacement's normal operation; d. a plurality of membranes sealing said plurality of bodies within said plurality of openings; e. wherein said plurality of membranes are comprised of a material which allows for said pharmaceutical to diffuse across said plurality of membranes; f. wherein said material further determines the diffusion rate of said pharmaceutical crossing said plurality of membranes.