ESTROGEN METABOLITE LEVELS AND CYP1B1 POLYMORPHISMS IN LUNG CANCER DIAGNOSIS, PROGNOSIS, AND RISK ASSESSMENT

摘要

Systems and methods for determining the prognosis of a patient having CYP1B1-mediated lung cancer and for diagnosing a risk of developing CYP1B1-mediated lung cancer are provided. The systems and methods comprise determinations of the concentration of estrogen metabolites in the lung tissue or a proxy thereof, or polymorphisms in the gene encoding the CYP1B1 protein, which metabolite concentrations or CYP1B1 polymorphisms are associated with a probability of surviving and/or a risk of developing lung cancer.

主权项

1. A system for determining a risk of developing lung cancer, comprising a data structure comprising one or more reference concentrations for one or more estrogen metabolites and optionally, one or more reference concentrations for one or more estrogen hormones, wherein the reference concentrations for the one or more estrogen metabolites and the reference concentrations for the one or more estrogen hormones comprise concentrations that indicate a subject is at risk for developing lung cancer, concentrations that indicate the subject has lung cancer, and concentrations that indicate the subject is not at risk for developing lung cancer; and, a processor operably connected to the data structure, wherein the processor is programmed to compare concentrations of estrogen metabolites determined from a sample obtained from a subject with the reference concentrations for the one or more estrogen metabolites in the data structure, and optionally is programmed to compare concentrations of an estrogen hormone determined from a sample obtained from a subject with the reference concentrations for the one or more estrogen hormones in the data structure, and is programmed to generate a lung cancer development risk score based on a comparison of determined estrogen metabolite concentrations with the reference concentrations for the one or more estrogen metabolites in the data structure, and optionally also based on a comparison of determined estrogen hormone concentrations with the reference concentrations for the one or more estrogen hormones in the data structure.