COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION

摘要

Dry reagent compositions are disclosed for maintaining and preserving enzymatic activity. Also disclosed are test elements incorporating the same and methods of making and using the same for determining the presence or amount of an analyte in a body fluid sample. The dry reagent compositions can include components such as a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof.

主权项

1. A dry composition comprising:
(a) a glucose dehydrogenase; (b) a redox cofactor; (c) an agent capable of eliciting a change in at least one optical property of an indicator reagent in the presence of redox equivalents; (d) an indicator reagent; and (e) at least one compatible solute being ectoine or a derivative thereof, wherein the derivative of ectoine is selected from the group consisting of hydroxyectoine, homoectoine, a hydroxyectoine ester, a hydroxyectoine ether, a sulfonyl derivative of ectoine or an esterified sulfonyl derivative of ectoine and an amide of a sulfonyl derivative of ectoine.