| 发明名称 |
METHODS FOR SUPPRESSING CANCER BY INHIBITION OF TMCC3 |
| 摘要 |
A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample. |
| 申请公布号 |
US2014363372(A1) |
申请公布日期 |
2014.12.11 |
| 申请号 |
US201414223800 |
申请日期 |
2014.03.24 |
| 申请人 |
DEVELOPMENT CENTER FOR BIOTECHNOLOGY ;CHANG GUNG MEMORIAL HOSPITAL ;ACADEMIA SINICA |
发明人 |
Yu Alice L.;Yu John;Wang Ya-Hui;Hsu Chuan-Lung;Chen Yi-Chang;Lok Ying-Yung |
| 分类号 |
C07K16/30;G01N33/574;C12Q1/68;A61K51/10 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating cancer, comprising: administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. |
| 地址 |
New Taipei City TW |
