SALUBRINAL-DRIVEN ATTENUATION OF MALIGNANT PHENOTYPES OF 4T1 BREAST CANCER CELLS

摘要

A method is disclosed for the in vivo treatment of a breast cancer tumor utilizing a therapeutically effective amount of an agent that inactivates the Rac1 GTPase and results in a reduction in cancer cell invasion, reduced cancer cell motility, and reduced volume and weight of the tumor. Agents that can be used in this treatment include salubrinal, guanabenz, and combinations thereof. The agents additionally have proven useful in reducing the development of osteoclastogenesis and reducing bone metastasis.

主权项

1. An in vivo method for treating a malignant tumor comprising:
(a) providing a mammal exhibiting a malignant tumor and producing Rac1 GTPase; and (b) treating the mammal with a therapeutically effective amount of a pharmaceutically acceptable agent capable of inactivating Rac1 GTPase.