发明名称 |
IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE USING COMPOUNDS INCLUDING TRIHYDROXYPHENYL GROUPS |
摘要 |
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof. |
申请公布号 |
WO2014197768(A1) |
申请公布日期 |
2014.12.11 |
申请号 |
WO2014US41240 |
申请日期 |
2014.06.06 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA;NORTHWESTERN UNIVERSITY |
发明人 |
HAI, TON, THAT;GREEN, JOHN-BRUCE, DEVAULT;FULGHUM, TIMOTHY, MICHAEL;MESSERSMITH, PHILLIP, BYRON;SILEIKA, TADAS, STANISLOVAS |
分类号 |
A61L27/00;G01N33/543;G01N33/551 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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