摘要 |
A humanized antibody, or a scFv, Fab, or F(ab')2 thereof, includes: a heavy chain variable region, or a homologous variant thereof, wherein the heavy chain variable region includes: heavy chain framework regions, CDRH1 that has the sequence of SEQ ID NO:19, CDRH2 that has the sequence of SEQ ID NO:20, and CDRH3 that has the sequence of SEQ ID NO:21, wherein the heavy chain variable region and the homologous variant share at least 90% sequence identity in the heavy chain framework regions; and a light chain variable region, or a homologous variant thereof, that includes: light chain framework regions, CDRL1 that has the sequence of SEQ ID NO:22, CDRL2 that has the sequences of SEQ ID NO:23, and CDRL3 that has the sequences of SEQ ID NO:24, wherein the light chain variable region and the homologous variant share at least 90% sequence identity in the light chain framework regions. |
申请人 |
DEVELOPMENT CENTER FOR BIOTECHNOLOGY;DCB-USA LLC |
发明人 |
WU, CHIA-CHENG;HUANG, CHAO-YANG;LIN, YU-YING;CHEN, YU-JUNG;LAI, JIANN-SHIUN |