发明名称 |
CELL MODEL AND SCREENING METHOD FOR SCREENING C-FMS KINASE INHIBITORS |
摘要 |
The present invention provides a cell model and a method for screening c-Fms tyrosine kinase inhibitors. Specifically, the present invention provides a cell that expresses macrophage colony stimulating factor receptor and STAT1 protein simultaneously. The present invention further provides a method for screening c-Fms tyrosine kinase inhibitors, a method for evaluating the inhibiting activity of a compound or a composition against c-Fms tyrosine kinase, and use of the cell in screening c-Fms tyrosine kinase inhibitors. The cell model established in the present invention is sensitive, highly effective and reliable, and can be used in high-throughput screening and/or high-content screening of c-Fms tyrosine kinase inhibitors. |
申请公布号 |
EP2692857(A4) |
申请公布日期 |
2014.12.10 |
申请号 |
EP20120762924 |
申请日期 |
2012.03.14 |
申请人 |
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA |
发明人 |
WANG, LILI;YANG, SHENGQIAN;LONG, LONG;XIAO, JUNHAI;LI, SONG |
分类号 |
C12N5/00;C07K14/53;C12N5/09;C12N9/12;C12Q1/48;C12R1/91 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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地址 |
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