COMBINATION THERAPY COMPRISING A GROWTH HORMONE VARIANT AND AN OLIGONUCLEOTIDE TARGETED TO THE GROWTH HORMONE RECEPTOR

摘要

The present disclosure relates to a method for treatment or prevention of diseases have an increased level of insulin-like growth factor I (IGF-I). The method comprises administration of a growth hormone (GH) variant having antagonistic activity in combination with an oligonucleotide targeted to growth hormone receptor (GHR) to a subject in need.