Indole derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic diseases containing same as active ingredient

摘要

The present invention relates to an indole derivative, The indole derivative according to the present invention effectively inhibits the activity of diacylglycerol acyltransferase (DGAT) which induces metabolic diseases, such as obesity, diabetes, hyperlipidemia, or fatty liver and the like in lipid metabolism, thereby effectively regulating lipid metabolism and energy metabolism, and thus can be useful in pharmaceutical compositions for preventing or treating metabolic disease.

主权项

1. An indole derivative represented by Formula 1 below or a pharmaceutically acceptable salt thereof: where, R1 is —H, C1-10 linear or branched alkyl group, C2-10 linear or branched alkenyl group, C3-12 cycloalkyl group, C3-12 cycloalkyl C1-5 alkyl group, C5-12 aryl group, C1-5 aryl C1-5 alkyl group, C5-12 aryl carbonyl group, C1-10 linear or branched alkyl carbonyl group or C1-10 linear or branched alkoxy carbonyl group; R2 is C5-12 aryl group or C5-12 heteroaryl group including one or more of N, O and S in a ring, wherein the aryl group or heteroaryl group is non-substituted or substituted with —OH, C1-10 linear or branched alkyl group, halogen or R5 is —H, —OH, —NH2, carboxyl group, amino carbonyl group, C1-10 linear or branched alkyl group, C1-5 linear or branched alkoxy group, C1-10 linear or branched alkoxy carbonyl group or C5-12 heterocycloalkyl group including one or more of N, O and S in a ring, n is an integer between 0-5; R3 is —H or C1-5 linear or branched alkyl group; R4 is —H, C1-5 linear or branched alkyl group or halogen; X is carbonyl group or sulfonyl group; and is single or double bond.