| 发明名称 | Mutant interleukin-2 (IL-2) polypeptides | ||
| 摘要 | The present invention relates to mutant IL-2 polypeptides that act as receptor antagonists. The mutant IL-2 polypeptides bind CD 25 but do not activate the IL-2 receptor. Also provided are methods of using the mutant IL-2 polypeptides, for example, to treat a patient who has cancer or a viral infection. The mutant polypeptides can also be used in various delivery systems. | ||
| 申请公布号 | US8906356(B2) | 申请公布日期 | 2014.12.09 |
| 申请号 | US200812741552 | 申请日期 | 2008.11.05 |
| 申请人 | Massachusetts Institute of Technology | 发明人 | Wittrup K. Dane;Liu David V. |
| 分类号 | C07K14/55;A61K38/20 | 主分类号 | C07K14/55 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Mandragouras, Esq. Amy E.;Frank Christopher L. |
| 主权项 | 1. A mutant interleukin-2 (IL-2) polypeptide comprising an amino acid sequence set forth in SEQ ID NO:2 and further comprising an amino acid substitution at position 91 and/or position 126 of SEQ ID NO: 2, wherein the polypeptide binds CD25 but does not activate the IL-2 receptor on T regulatory cells. | ||
| 地址 | Cambridge MA US | ||