| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:
R1 is formula (a) or (b): A is CH2 or CH2CH2;Z1 and Z2, are each independently —C(O)O(alkyl), aryl, or monocyclic heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of C1-C6 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halogen, C1-C6 haloalkyl, CN, ORa, NRbRc, —C(O)NRbRc, and —S(O)2NRbRc; wherein Ra, Rb, and Rc, at each occurrence, are each independently hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;R2 is hydrogen or C1-C6 alkyl wherein the C1-C6 alkyl is optionally substituted with C1-C6 haloalkyl, alkoxy, or haloalkoxy, and R3 is: wherein
R4 is C1-C6 alkyl, O(C1-C6 alkyl), or O(C1-C6 haloalkyl);R5, R6, R7, R8, R9, R10, and R11, are each independently hydrogen, C1-C6 alkyl, or halogen;or R2 and R3, together with the nitrogen atom to which they are attached, form a ring of formula (i), (ii), or (iii): wherein:
R12, at each occurrence, represents an optional substituent on any substitutable carbon atom, and is independently C1-C6 alkyl, C1-C6 haloalkyl, CN, OH, or halogen;n is 0, 1, or 2;p is 1 or 2;q is 1 or 2;G1 is aryl which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C1-C6 alkyl, halogen, C1-C6 haloalkyl, OH, alkoxy, haloalkoxy, CN, —C(O)OH, —C(O)O(alkyl), —(C1-C6 alkylenyl)-OH, —(C1-C6 alkylenyl)-C(O)OH, or tetrazolyl;R13 is hydrogen, C1-C6 alkyl, or —(C1-C6 alkylenyl)-O(alkyl);R14, R15, R16, R17, R18, R19, and R20, are each independently hydrogen or C1-C6 alkyl;X is CH2, O, N(Rw) wherein Rw is hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;r is 1 or 2;s is 0, 1, 2, 3, or 4; andR21, at each occurrence, represents an optional substituent on any substitutable carbon atom of the bicyclic ring, and is independently halogen, C1-C6 alkyl, or C1-C6 haloalkyl. |
