Proceso para preparar un compuesto de formula (xiv) o un anhidrido de acido borico del mismo.
摘要
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of the peptide boronic acid proteasome inhibitor bortezomib.
申请公布号
CL2014002252(A1)
申请公布日期
2014.12.05
申请号
CL20140002252
申请日期
2014.08.25
申请人
MILLENNIUM PHAMACEUTICALS, INC.
发明人
LO, YOUNG;KULKARNI, VITHALANAND R.;CHIU, FANG-TING;MUNK, STEPHEN;AMMOSCATO, VINCENT