| 发明名称 |
COMPOSITION FOR TARGET MEMBRANE PROTEIN DEPLETION |
| 摘要 |
A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions. |
| 申请公布号 |
US2014356366(A1) |
申请公布日期 |
2014.12.04 |
| 申请号 |
US201414290447 |
申请日期 |
2014.05.29 |
| 申请人 |
Samsung Electronics Co., Ltd. |
发明人 |
CHEONG Kwang Ho;Lee Seung Hyun;Cho Mi Young;Koh Young Jun;Powei Lin;Yi Christina;Hwang Jae Woong |
| 分类号 |
C07K16/46;C07K16/28;C07K16/40 |
主分类号 |
C07K16/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of target membrane protein depletion, comprising
treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein is associated with the cell membrane where the target membrane protein is positioned, and is internalized into the cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein. |
| 地址 |
Suwon-si KR |
