摘要 |
Invented are methods for treating cancer in a human in need thereof which comprises the administration of a therapeutically effective amount of a combination of: N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a salt or solvate thereof; and N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a salt or solvate thereof, to such human. Also invented are methods of treating cancer in a human in need thereof which comprises the administration of a therapeutically effective amount of a combination of: N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide and N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate, to such human. |
申请人 |
GLAXOSMITHKLINE LLC |
发明人 |
BEHBAHANI, ROYA;CARSON, ROBIN, L.;CORNFELD, MARK, J.;DABROWSKI, CHRISTINE, E.;GILMER, TONA, M.;GOODMAN, VICKI, L.;GUCKERT, MARY, E.;HUGHES-EARLE, ANGELA;LANE, STEPHEN, R.;LEGOS, JEFFREY, J.;MARTIN, ANNE-MARIE;OUELLET, DANIELE;PATEL, KIRAN, A.;RICHARDS, ERIC, M.;RICHARDS-PETERSON, LAUREN, E.;RUDO, SHARON;SUN, PENG;SWANN, R., SUZANNE |