TOPICALLY APPLIED PHARMACEUTICAL COMPOSITION, METHOD OF PREPARING IT AND ITS USE

摘要

A topically applicable pharmaceutical composition comprises at least one liquid lipid, at least one pharmaceutical active ingredient which is soluble in at least o ne of the liquid lipids and is re-absorbed by the skin, and a hydrous gel which is the main component of the composition, whereby at least one lipid and at least one active ingredient a re worked into the gel and the composition is essentially free of emulsifying agents and solid constituents, with the exception of the necessary gelatinizing agent required to form the hydrous gel. All of the active ingredients are present in dissolved form, whereby at least on e active ingredient is dissolved in the liquid lipid, and this lipid containing the dissolved active ingredient is itself the internal phase and is worked into the hydrous gel a s the external phase. The composition is also essentially free of surface-active substances . Process for manufacturing a topically applicable pharmaceutical composition of this kind which provides for the fact that at least one active ingredient re- absorbable by the skin is dissolved, preferably in concentrated form, in a lipid and that this solution is intermingled as the internal phase in a hydrous gel as the external phase, whereby this hydrous gel is the main component in the composition. The composition obtained thereby is highly stable and has favorable galen ic properties.