Windowing Combined with Ion-Ion Reactions for Chemical Noise Elimination

摘要

In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.

主权项

1. A system for identifying a singly charged ion of a compound from multiply charged chemical noise ions in mass spectrometry, comprising:
a mass spectrometer that
selects a plurality of ionized molecules of an ion source that have mass-to-charge ratios within a mass-to-charge ratio window width in a first location,transmits the plurality of selected ionized molecules from the first location to a second location,transmits a plurality of reagent ions to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules;analyzes the plurality of reduced ionized molecules, andproduces a mass spectrum using a mass analyzer; and a processor that identifies a compound from a mass peak of the mass spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the mass-to-charge ratio window width.