发明名称 |
Methods and compositions for treating amyloid deposits |
摘要 |
<p>The present disclosure provides methods of delivering a protective ApoE isoform to the central nervous system of a mammal, comprising administering to the cerebrospinal fluid (CSF) of the mammal an rAAV particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding the protective ApoE isoform inserted between a pair of AAV inverted terminal repeats in a manner effective to infect ependymal cells in the non-rodent mammal such that the ependymal cells secrete the ApoE into the CSF of the mammal.</p> |
申请公布号 |
AU2013263346(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
AU20130263346 |
申请日期 |
2013.03.14 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;THE GENERAL HOSPITAL CORPORATION |
发明人 |
DAVIDSON, BEVERLY L.;HYMAN, BRADLEY T. |
分类号 |
C12N15/861 |
主分类号 |
C12N15/861 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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