| 发明名称 |
PREPARATION METHOD OF LYCOPENE INTERMEDIATE 3-METHYL-4,4-DIALKOXY-1-BUTALDEHYDE |
| 摘要 |
Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value. |
| 申请公布号 |
US2014357900(A1) |
申请公布日期 |
2014.12.04 |
| 申请号 |
US201214369137 |
申请日期 |
2012.12.10 |
| 申请人 |
NANJING UNIVERSITY OF TECHNOLOGY ;ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY |
发明人 |
Lv Chunlei;Pl Shiqing;Chen Jianhui;Lu Dingqiang;Ouyang Pingkai |
| 分类号 |
C07C45/30;C07C41/22 |
主分类号 |
C07C45/30 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A preparation method of lycopene intermediate 3-methyl-4, 4-dialkoxy-1-butyraldehyde, comprising the following steps:
Step (1): reacting 2-methyl-3,3-dialkoxy-1-halopropane of Formula (2) with magnesium powder in a solvent of anhydrous tetrahydrofuran at a temperature of 45-65° C. to generate a mixture of Grignard reagent under the protection of an inert gas; and Step (2): adding N,N-disubstituted carboxamide to the mixture of Grignard reagent and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde of Formula (1), its reaction equation is described as follows: wherein R is alkyl. |
| 地址 |
Nanjing City CN |
