Described are recombinant AAV vectors characterized in that they carry capsid protein modification(s) resulting in a reduced or eliminated heparin binding function. The AAV vectors of the present invention are particularly suitable for gene therapy by systemic application, since (a) transduction of the liver is eliminated or at least drastically reduced and (b) the transduction efficiency of non-hepatic tissues is increased.
申请公布号
WO2004111248(A2)
申请公布日期
2004.12.23
申请号
WO2004EP06222
申请日期
2004.06.09
申请人
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS;KLEINSCHMIDT, JUERGEN;MUELLER, OLIVER