PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR

摘要

The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.

主权项

1. A method for the preparation of a compound of general formula (2) comprising contacting a compound of general formula (3) with an alcohol of general formula R4—OH and an acetal or an alkoxy-alkene or a ketone in the presence of an acid wherein X is halogen and wherein R2 and R3 each independently stand for an alkyl with 1 to 12 carbon atoms, an alkenyl with 1 to 12 carbon atoms, a cycloalkyl with 3 to 7 carbon atoms, a cycloalkenyl with 3 to 7 carbon atoms, an aryl with 6 to 10 carbon atoms or an aralkyl with 7 to 12 carbon atoms, wherein each of R2 and R3 may be substituted and wherein R2 and R3 may form a ring together with the carbon atom to which they are bound, characterized in that R4 is an alkyl or alkenyl group with 2 to 6 carbon atoms.