CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE

摘要

The present invention provides cyclic aminomethyl pyrimidine derivatives and pharmaceutically permissible salts thereof that exhibit high selectivity for dopamine D4 receptors and are useful as therapeutic agents for attention deficit hyperactivity disorder, etc. Specifically, compounds represented by formula (1) and pharmaceutically permissible salts thereof are provided. [In the formula, n and m each independently represent 1 or 2; Ra represents a C1-6 alkyl group, C3-6 cycloalkyl group or amino group; Rb represents a hydrogen atom, C1-6 alkyl group, etc. (provided that when Ra is an amino group, Rb is a hydrogen atom); Rc1 and Rc2 each independently represent a hydrogen atom or a C1-6 alkyl group; Rd1 and Rd2 each independently represent a hydrogen atom or fluorine atom; the ring Q represents a pyridyl group that may be substituted or an isoquinolinyl group that may be substituted; and the bond comprising the dotted line represents a single bond or a double bond.]