发明名称 |
METHOD FOR ENHANCING REMYELINATION USING GLI1 INHIBITORS |
摘要 |
The invention provides a method of treatment of multiple sclerosis and other neurological disorders characterized by myelin loss or myelin deficiency by inhibiting Gli1 transcription factor. In a related aspect, the invention provides a method for enhancing neuroprotection of a central nervous system (CNS) or peripheral nervous system (PNS) neuron in a subject in need thereof comprising administering to said subject an effective amount of a Gli1 inhibitor. In one embodiment, the subject has a neurological disorder characterized by myelin loss or myelin deficiency. |
申请公布号 |
EP2806948(A1) |
申请公布日期 |
2014.12.03 |
申请号 |
EP20130741571 |
申请日期 |
2013.01.25 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
SALZER, JAMES L.;SAMANTA, JAYSHREE;FISHELL, GORDON J. |
分类号 |
A61P25/00;A61K31/4436;A61K31/496 |
主分类号 |
A61P25/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|