Medical devices for the release of therapeutic agents

摘要

According to one aspect of the invention, medical devices are provided which contain the following: (a) an interior region that contains at least one degradation promoting agent and (b) an exterior region disposed over the interior region that contains at least one biodegradable polymer and at least one therapeutic agent.

主权项

1. A medical device comprising: (a) a metallic substrate which is a metal stent body; (b) a biodisintegrable interior region disposed directly on said substrate, that comprises a degradation promoting agent selected from organic acids, polyoxyalkylene homopolymers, polyoxyalkylene copolymers, polyoxyalkylene esters, polyoxyalkylene ethers, or combination thereof, and particulate poragenic agents and does not comprise a biodegradable polymer and (c) a biodisintegrable exterior region, disposed between the interior region and an exterior environment of the device, which comprises a biodegradable polymer and a therapeutic agent.