| 主权项 |
1. An aerosolized formulation, comprising:
a first insulin derivative having an isoelectric point (p1) ranging from about 6.5 to about 7.5, wherein the first insulin derivative is glargine insulin; a second insulin or insulin derivative; Trehalose; Leucine; a liquid carrier, which is water, ethanol, ethanol-water, or saline; and a precipitating agent, which is a free cation selected from at least one of zinc, copper, cobalt, iron, manganese, vanadium, cadmium, magnesium, calcium, and barium; wherein the first insulin derivative and the precipitating agent are dissolved in the liquid carrier; wherein the molar ratio of the precipitating agent to the first insulin derivative is from about 1:3 to about 5:1; wherein the first insulin derivative is present in an amount of from about 20 weight % to about 99 weight %. |
