| 摘要 |
Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:; |
| 主权项 |
1. A compound, or pharmaceutically acceptable salt thereof, of Formula Ib: wherein: R1, R3, R6, and R8 are H; R2 is pyridylR12; R5 is selected from the group consisting of -arylR12 and -heteroarylR12; each R9 is independently selected from the group consisting of H, C1-6 alkyl, —CF3, —(C1-9 alkyl)ncarbocyclyl, and —(C1-9 alkyl)naryl; alternatively, two adjacent R9, may be taken together to form a fused ring with the nitrogen; each R12 is 1-5 substituents each selected from the group consisting of H, C1-6 alkyl, halide, —CF3, —CN, —NHC(═O)R9, and —NHC(═O)N(R9)2; Y1, Y2, and Y4 are carbon; Y3 is nitrogen and R7 is absent; and each n is 0 or 1. |
