发明名称 ASSESSMENT OF RELATIVE PROPORTIONS OF ADRENERGIC AND CHOLINERGIC NERVOUS RECEPTORS WITH NON-INVASIVE TESTS
摘要 A system and method for assessing relative proportions of cholinergic and adrenergic nervous receptors in a patient is disclosed. The system includes: an anode, a cathode, and passive electrode for placement on different regions of the patient body. The method generally includes: applying DC voltage pulses of varying voltage values to stress sweat glands of the patient, collecting data representing the current between the anode and the cathode and the potential of the anode, the cathode, and the passive electrode for each of the different DC voltage, and computing data representing the electrochemical skin conductance of the patient. The computed data representing the electromechanical skin conductance of the patient is reconciled with reference data from control patients having known relative proportions of cholinergic and adrenergic nervous receptors. Thus, the relative proportions of cholinergic and adrenergic nervous receptors in the patient can be determined.
申请公布号 US2014350432(A1) 申请公布日期 2014.11.27
申请号 US201414455194 申请日期 2014.08.08
申请人 lMPETO MEDICAL 发明人 Khalfallah Kamel;Brunswick Philippe
分类号 A61B5/00;A61B5/053 主分类号 A61B5/00
代理机构 代理人
主权项 1. A method for assessing relative proportions of cholinergic and adrenergic nervous receptors of a patient, the method being performed in a system comprising: an anode and a cathode, intended to be placed on different regions of the patient body, a plurality of passive electrodes, intended to be placed on different regions of the patient body and connected to a mass with high impedances, an adjustable DC source, that is controlled in order to feed the anode with a DC current,the method comprising the following steps: applying DC voltage pulses of varying voltage values in order to stress sweat glands of the patient, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body in the vicinity of the electrodes, collecting data representative of the current between the anode and the cathode, and of the potential of the anode, the cathode and of at least one passive electrodes, for the different DC voltages, from said data, computing data representative of the electrochemical skin conductance of the patient, reconciling said data representative of the electrochemical skin conductance of the patient with reference data obtained in the same conditions on patients having known relative proportions of cholinergic and adrenergic nervous receptors, and determining relative proportions of cholinergic and adrenergic nervous receptors of the patient.
地址 Paris FR
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