METHODS OF ADMINISTERING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-{4-[7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YL]PHENYL}UREA TO TREAT PROLIFERATIVE DISEASE

摘要

PROBLEM TO BE SOLVED: To provide Fms-like tyrosine kinase 3 (FLT3) inhibitors and methods of administering them, in order to treat proliferative disease in mammals.SOLUTION: This invention relates to methods for treating proliferative disease using urea derivatives represented by the formula (I). This invention also relates to administration, regimens and pharmaceutical preparations wherein a therapeutically effective amount is at least 12 mg per day. This invention also relates to methods of treating proliferative diseases or FLT-3 mediated diseases in humans.