BISMUTH-CONTAINING COMPOUNDS FOR MODULATING PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS
摘要
Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.
申请公布号
EP2637674(A4)
申请公布日期
2014.11.26
申请号
EP20110839065
申请日期
2011.11.08
申请人
SYNTHONICS, INC.
发明人
PRICE, JOHN, D.;PICCARIELLO, THOMAS;OBERLENDER, ROBERT, A.;MULHARE, MICHAELA, E.;PALMER, SCOTT, B.