| 摘要 |
The invention is directed to compounds of Formula I:;wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided. |
| 主权项 |
1. A compound of Formula I: wherein: W is wherein R4═H, F, Cl, Br, I, OH, OCH3, OCH2CH3, —C(1-3)alkyl, —CO2R5, CONR6R7, C══CR8, or CN; wherein
R5═H, or —C(1-3)alkyl;R6═H, or —C(1-3)alkyl;R7═H, or —C(1-3)alkyl; andR8═H, —CH2OH, or —CH2CH2OH; R2 is cycloalkyl, spiro-substituted cycloalkenyl, heterocyclyl, spiro-substituted piperidinyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy C(1-3)alkyl, and C(1-4)alkyl; X is selected from the group consisting of: wherein R1 and R10 are independently H, —CH3, or —C2-C5 alkyl, optionally substituted with one or two of: Me, Et, OH, NH2, NHMe, NMe2, NHEt, NEt2, pyrrolidinyl, pyridyl, morpholino, CONH2, or COOH and such that when any two heteroatoms are attached to said C2 to C5 alkyl group there exists at least two carbon atoms between them, and R3 is —SO2Me, SO2Et, —CO2R9, —NO2, or —CN;
wherein R9 is H, or C(1-3)alkyl; Z is H, F, Cl, Br, C1-C3 alkyl or —CH2OH; and J is CH or N; or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. |
