发明名称 |
Método para isolar uma forma tetramérica de uricase a partir de uma solução de uricase purificada |
摘要 |
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75 % of the uricolytic activity of the unmodified enzyme. |
申请公布号 |
BR9917760(B1) |
申请公布日期 |
2014.11.25 |
申请号 |
BR19999917760 |
申请日期 |
1999.08.02 |
申请人 |
DUKE UNIVERSITY;MOUNTAIN VIEW PHARMACEUTICALS, INC. |
发明人 |
MICHAEL S. HERSHFIELD;SUSAN J. KELLY;MARK G. P. SAIFER;MERRY R. SHERMAN;DAVID L. WILLIAMS |
分类号 |
A61K47/48;C12N15/09;A61K31/495;A61K38/00;A61K38/44;A61P13/02;A61P13/12;A61P19/06;A61P43/00;C12N9/06;C12N11/08;C12R1/67 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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