| 发明名称 | Mutated ACVR1 for diagnosis and treatment of Fibrodyplasia Ossificans Progressiva (FOP) | ||
| 摘要 | This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis and treatment of Fibrodysplasia Ossificans Progressiva (FOP). | ||
| 申请公布号 | US8895711(B2) | 申请公布日期 | 2014.11.25 |
| 申请号 | US200712296275 | 申请日期 | 2007.04.17 |
| 申请人 | The Trustees of the University of Pennsylvania | 发明人 | Kaplan Frederick S.;Shore Eileen M. |
| 分类号 | C07H21/02;C12Q1/68;C12P19/34;C07K14/47;G01N33/68;C07K14/71;C07K14/00;C12N15/85;A61K38/00 | 主分类号 | C07H21/02 |
| 代理机构 | Pearl Cohen Zedek Latzer Baratz LLP | 代理人 | Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP |
| 主权项 | 1. A molecular beacon nucleic acid comprising a stem and a loop and a detectable label, wherein the loop consists of at least 15 contiguous bases of SEQ ID NO: 34 or of at least 15 contiguous bases of the complement of SEQ ID NO: 34, wherein position 11 of SEQ ID NO: 34 is an A. | ||
| 地址 | Philadelphia PA US | ||