HIDTIL UKENDTE CYTOTOKSISKE T-CELLEEPITOPER OG POLYEPITOPER FOR HUMAN CYTOMEGALOVIRUS (HCMV), PRÆPARATER, DER OMFATTER DISSE, OG DIAGNOSTISKE OG PROFYLAKTISKE OG TERAPEUTISKE ANVENDELSER DERAF

摘要

The present invention provides CTL epitope peptides and polyepitope peptides from 14 distinct antigens of human cytomegalovirus (HCMV) that are restricted through HLA the must commonly prevalent class I alleles in different ethnic populations of the world. These epitopes provide an important platform for CTL epitope-based vaccines against HCMV. The present invention further provides vaccine compositions comprising the subject epitope and polyepitope peptides and methods for vaccination of humans and for the adoptive transfer of HCMV-specific T cells to human subjects. The present invention further provides reagents and methods for determining the HCMV status or level of HCMV-specific immunity of a subject.