发明名称 |
USE OF BENZOPHENONE DERIVATIVE OR SALT THEREOF AND TNFALFA INHIBITOR IN COMBINATION AND PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVE OR SALT THEREOF AND THE INHIBITOR |
摘要 |
Disclosed are use of a benzophenone derivative represented by general formula (I) or a salt thereof and one or more TNF± inhibitors in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereof and one or more TNF± inhibitors. The use and the composition are useful for treatment or prevention of autoimmune diseases and the like. (In the formula, R 1 represents an optionally substituted heterocyclic group, a substituted phenyl group or the like; Z represents an alkylene group or the like; R 2 represents a carboxyl group, which may be protected by an alkyl group, or the like; R 3 represents an optionally protected hydroxyl group or the like; R 4 represents an optionally substituted cycloalkyloxy group or the like; and R 5 represents a hydrogen atom or the like.) |
申请公布号 |
HRP20140961(T1) |
申请公布日期 |
2014.11.21 |
申请号 |
HR2014P000961T |
申请日期 |
2014.10.06 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
AIKAWA, YUKIHIKO;SHIOZAWA, SHUNICHI |
分类号 |
A61K31/12;A61K31/194;A61K31/423;A61K31/5377;A61K39/395;A61K45/00;A61K45/06;A61P1/00;A61P1/16;A61P13/12;A61P19/02;A61P29/00;A61P37/02;A61P37/06;A61P43/00;C07D261/20 |
主分类号 |
A61K31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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