RBP1 as a Molecular Biomarker for Predicting Survival and Response to Treatment in Glioma

摘要

Disclosed herein are methods for detecting the presence of an isocitrate dehydrogenase mutation in a sample from a subject. Also disclosed are methods diagnosing and treating subjects having a cancer including determining whether the cancer may likely be treated with one or more retinoids.

主权项

1. An assay for detecting the presence of an isocitrate dehydrogenase mutation in a sample obtained from a subject which comprises
determining the methylation status of all or part of the retinol-binding protein 1 (RBP1) promoter in the sample, wherein the presence of the isocitrate dehydrogenase mutation is indicated where the methylation status is hypermethylated.