发明名称 |
Chimpanzee adenovirus vaccine carriers |
摘要 |
CHIMPANZEE ADENOVIRUS VACCINE CARRIERS Abstract 5 The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human El-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The 10 invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer. |
申请公布号 |
AU2011247887(B2) |
申请公布日期 |
2014.11.20 |
申请号 |
AU20110247887 |
申请日期 |
2011.11.09 |
申请人 |
MSD ITALIA S.R.L. |
发明人 |
CIRILLO, AGOSTINO;NICOSIA, ALFREDO;COLLOCA, STEFANNO;ERCOLE, BRUNO BRUNI;SPORENO, ELISABETTA;MEOLA, ANNALISA |
分类号 |
C12N15/861;A61K38/00;A61K39/00;A61K45/06;A61K48/00;C07K14/075;C07K14/16;C07K14/18;C07K14/705;C12N7/02;C12N7/04;C12N15/86 |
主分类号 |
C12N15/861 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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