| 主权项 |
1. A compound of Formula (I) or pharmaceutically acceptable salts thereof: wherein: A is a cyclic group independently selected from aryl, heteroaryl, heterocyclic, C3-C8 cycloalkyl, and C3-C8 cycloalkenyl, wherein A is substituted with -L-E or -L3-D, which are defined below; W is (a) absent; or (b) an optionally substituted aliphatic group; wherein W, when present, is substituted with -L-E or -L3-D, which are defined below; T is (a) absent; or (b) an optionally substituted linear aliphatic group containing zero to eight carbons; wherein T, when present, is substituted with -L-E or -L3-D, which are defined below; G is (a) absent; or (b) independently selected from optionally substituted aryl and optionally substituted heteroaryl; wherein G, when present, is substituted with -L-E or -L3-D, which are defined below; wherein one or two of W, G, and T can optionally be absent; R1 and R2 at each occurrence are each independently selected from the group consisting of hydrogen, halogen, cyano, optionally substituted C1-C4 alkyl, —O—R11, —NRaRb, —C(O)R11, —CO2R11, and —C(O)NRaRb; wherein at least one of R1 and R2 can be optionally substituted with -L-E or -L3-D as defined below; R11 at each occurrence is independently hydrogen or optionally substituted C1-C8 alkyl; Ra and Rb at each occurrence are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8, alkyl, and optionally substituted C2-C8 alkenyl; or Ra and Rb can be taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocyclic or optionally substituted heteroaryl group; u and v at each occurrence are each independently 1, 2, or 3; Q and J are each independently selected from: R3 and R4 at each occurrence are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8, alkyl, optionally substituted C2-C8, alkenyl, and optionally substituted C3-C8, cycloalkyl; or alternatively, R3 and R4 can be taken together with the carbon atom to which they are attached to form optionally substituted C3-C8, cycloalkyl or optionally substituted heterocyclic; R5 at each occurrence is independently hydrogen, optionally substituted C1-C8, alkyl, or optionally substituted C3-C, cycloalkyl; R6 at each occurrence is independently selected from the group consisting of —C(O)—R12, —C(O)—C(O)—R12, —S(O)2—R12, and —C(S)—R12; R12 at each occurrence is independently selected from the group consisting of: —O—R11, —NRcRd; R13 at each occurrence is independently selected from the group consisting of hydrogen, C1-C8, alkyl, C2-C8, alkenyl, C2-C8, alkynyl, C3-C8, cycloalkyl, C3-C8, cycloalkenyl, heterocyclic, aryl, and heteroaryl, each optionally substituted; or Rc and Rd at each occurrence are each independently selected from the group consisting of hydrogen, —R13, —C(O)—R13, —C(O)—OR13, —S(O)2—R13, —C(O)N(R13)2, and —S(O)2N(R13)2; m is 0, 1, or 2; n is 1, 2, 3, or 4; X at each occurrence is independently selected from O, S, S(O), SO2, and C(R7)2, provided that when m is 0, X is C(R7)2; or R7 at each occurrence is independently selected from the group consisting of hydrogen, halogen, —C1-C4 alkyl, cyano, —O—R11, —NRaRb, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted with —C1-C4 alkyl; or two vicinal R7 groups can be taken together with the two adjacent atoms to which they are attached to form a fused, optionally substituted C3-C8, cycloalkyl or optionally substituted heterocyclic ring; or alternatively two geminal R7 groups can be taken together with the carbon atom to which they are attached to form a spiro, optionally substituted C3-C8 cycloalkyl or optionally substituted heterocyclic ring; L-E or -L3-D are as follows: E is (i) C3-C14 carbocycle or 3- to 14-membered heterocycle, and is optionally substituted with one or more RA; or (ii) E is -LS-RE; L is -LS-, -LS-O-LS′-, -LS-C(O)-LS′-, -LS-S(O)2-LS′-, -LS-S(O)-LS′-, -LS-OS(O)2-LS′-, -LS-S(O)2O-LS′-, -LS-OS(O)-LS′-, -LS-S(O)O-LS′-, -LS-C(O)O-LS′-, -LS-OC(O)-LS′-, -LS-OC(O)O-LS′-, -LS-C(O)N(RB)-LS′-, -LS-N(RB)C(O)-LS′-, -LS-C(O)N(RB)O-LS′-, -LS-N(RB)C(O)O-LS′-, -LS-C(O)N(RB)-LS′-, -LS-C(O)N(RB)N(RB′)-LS′-, -LS-S-LS′-, -LS-C(S)-LS′-, -LS-C(S)O-LS′-, -LS-OC(S)-LS′-, -LS-C(S)N(RB)-LS′-, -LS-N(RB)-LS′-, -LS-N(RB)C(S)-LS′-, -LS-N(RB)S(O)-LS′-, -LS-N(RB)S(O)2-LS′-, -LS-S(O)2N(RB)-LS′-, -LS-S(O)N(RB)-LS′-, -LS-C(S)N(RB)O-LS′-, -LS-C(O)N(RB)C(O)-LS′-, -LS-N(RB)C(O)N(RB′)-LS′-, -LS-N(RB)SO2N(RB′)-LS′-, -LS-N(RB)S(O)N(RB′)-LS′-, or -LS-C(S)N(RB)N(RB′)-LS′-; LS and LS′ are each independently selected at each occurrence from bond; or C1-C6alkylene, C2-C6 alkenylene or C2-C6 alkynylene, each of which is independently optionally substituted at each occurrence with one or more RL; RA is independently selected at each occurrence from halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphonoxy, or phosphono; or -LS-RE; RB and RB′ are each independently selected at each occurrence from hydrogen; or C1-C6alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C3-C6 carbocycle or 3- to 6-membered heterocycle; or C3-C6 carbocycle or 3- to 6-membered heterocycle; wherein each C3-C6 carbocycle or 3- to 6-membered heterocycle in RB or RB′ is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C1-C6 haloalkynyl; RE is independently selected at each occurrence from —O—RS, —S—RS, —C(O)RS, —OC(O)RS, —C(O)ORS, —N(RSRS′), —S(O)RS, —SO2RS, —C(O)N(RSRS′), —N(RS)C(O)RS′, —N(RS)C(O)N(RS′RS″), —N(RS)SO2RS′, —SO2N(RSRS′), —N(RS)SO2N(RS′RS″), —N(RS)S(O)N(RS′RS″), —OS(O)—RS, —OS(O)2—RS, —S(O)2ORS, —S(O)ORS, —OC(O)ORS, —N(RS)C(O)ORS′, —OC(O)N(RSRS′), —N(RS)S(O)—RS′, —S(O)N(RSRS′) or —C(O)N(RS)C(O)—RS′; or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C3-C6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl; RL is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, —O—RS, —S—RS, —C(O)RS, —OC(O)RS, —C(O)ORS, —N(RSRS′), —S(O)RS, —SO2RS, —C(O)N(RSRS′) or —N(RS)C(O)RS′; or C3-C6carbocycle 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl; RS, RS′ and RS″ are each independently selected at each occurrence from hydrogen; C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in RS, RS′ or RS′ is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl; L3 is bond or -LS-K-LS′-, wherein K is selected from bond, —O—, —S—, —N(RB)—, —C(O)—, —S(O)2—, —S(O)—, —OS(O)—, —S(O)2—, —S(O)2O—, —S(O)O—, —C(O)O—, —OC(O)—, —OC(O)O—, —C(O)N(RB)—, —N(RB)C(O)—, —N(RB)C(O)O—, —OC(O)N(RB)—, —N(RB)S(O)—, —N(RB)S(O)2—, —S(O)N(RB)—, —S(O)2N(RB)—, —C(O)N(RB)C(O)—, —N(RB)C(O)N(RB′)-, —N(RB)SO2N(RB′)-, or —N(RB)S(O)N(RB′)-; D is C3-C12 carbocycle or 3- to 12-membered heterocycle, and is optionally substituted with one or more RA; or D is C3-C12 carbocycle or 3- to 12-membered heterocycle which is substituted with J and optionally substituted with one or more RA, where J is C3-C12 carbocycle or 3- to 12-membered heterocycle and is optionally substituted with one or more RA, or J is —SF5; or D is hydrogen or RA; RA is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -LS-RE, wherein two adjacent RA, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; RB and RB′ are each independently selected at each occurrence from hydrogen; or C1-C6alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in RB or RB′ is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C2-C6haloalkenyl or C2-C6haloalkynyl; RE is independently selected at each occurrence from —O—RS, —S—RS, —C(O)RS, —OC(O)RS, —C(O)ORS, —N(RSRS′), —S(O)RS, —SO2RS, —C(O)N(RSRS′), —N(RS)C(O)RS′, —N(RS)C(O)N(RS′RS″), —N(RS)SO2RS′, —SO2N(RSRS′), —N(RS)SO2N(RS′RS″), —N(RS)S(O)N(RS′RS″), —OS(O)—RS, —OS(O)2—RS, —S(O)2RS, —S(O)ORS, —C(O)ORS, —N(RS)C(O)ORS′, —OC(O)N(RSRS′), —N(RS)S(O)—RS′, —S(O)N(RSRS′), —P(O)(ORS)2, or —C(O)N(RS)C(O)—RS′; or C1-C6alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C3-C6 carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C(O)ORS, or —N(RSRS′); RL is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, —ORS, —S—RS, —C(O)RS, —OC(O)RS, —C(O)ORS, —N(RSRS′), —S(O)RS, —SO2RS, —C(O)N(RSRS′) or —N(RS)C(O)RS′; or C3-C6 carbocycle 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl; wherein two adjacent RL, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; LS and LS′ are each independently selected at each occurrence from bond; or C1-C6alkylene, C2-C6alkenylene or C2-C6alkynylene, each of which is independently optionally substituted at each occurrence with one or more RL; and RS, RS′ and RS″ are each independently selected at each occurrence from hydrogen; C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, —O—C1-C6 alkyl, —O—C1-C6 alkylene-O—C1-C6 alkyl, or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in RS, RS′ or RS′ is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl. |
