PREPARATION METHOD OF AZOXYSTROBIN

摘要

Disclosed in the present invention is a preparation method of Azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an etherification reaction by reacting the compound having a structure shown by formula (2) with 2-cyanophenol and/or a salt thereof under the catalysis of an azabicyclo tertiary amine compound and/or a salt thereof as the catalyst in a butyl acetate medium to obtain a butyl acetate solution containing Azoxystrobin; and b) cooling the butyl acetate solution containing Azoxystrobin to precipitate Azoxystrobin having a structure as shown by formula (1) from the butyl acetate solution. Using the method provided by the present invention to prepare Azoxystrobin can significantly improve the yield of Azoxystrobin, and can obtain Azoxystrobin products having high purity.