| 摘要 |
<p>The present invention relates to compounds, peptides or peptidomimetics that inhibit, reduce or prevent protease activity and the use of these compounds, peptides or peptidomimetics to treat or prevent a condition. In particular the condition may be periodontal disease including chronic periodontitis. The protease activity may be activity of a gingipain. The compounds, peptides or peptidomimetics of the invention may also be used in assays for the identification of protease inhibitors. The compound, peptide or peptidomimetic of the invention may comprise an amino acid sequence of a Kgp propeptide or fragment thereof, wherein the compound, peptide or peptidomimetic does not have the capacity to form a dimer.</p> |
