发明名称 |
Amido-amine polymer compositions |
摘要 |
Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans. |
申请公布号 |
US8889738(B2) |
申请公布日期 |
2014.11.18 |
申请号 |
US201213417592 |
申请日期 |
2012.03.12 |
申请人 |
Genzyme Corporation |
发明人 |
Dhal Pradeep K.;Holmes-Farley Stephen Randall;Huval Chad C. |
分类号 |
A61K31/22;A61K31/04;A61K31/785;A61K31/23;A61K31/165 |
主分类号 |
A61K31/22 |
代理机构 |
Genzyme Corporation |
代理人 |
Genzyme Corporation |
主权项 |
1. A method of removing a compound or ion from the gastrointestinal tract of an animal comprising administering to the animal an effective amount of a pharmaceutical composition comprising:
a) a copolymer derived from compounds according to the following Formulas I and II: wherein R1 independently represents a hydrogen radical —RNH2, —R—N—(R—NH2)2 or —R—N—(R—N—(R—NH2)2)2, wherein R independently represents a branched or unbranched, substituted or unsubstituted alkyl radical, with the proviso that at least one R1 is not a hydrogen radical; R2 independently represents a hydrogen radical or a branched or unbranched, substituted or unsubstituted alkyl radical; and b) a pharmaceutically acceptable excipient. |
地址 |
Cambridge MA US |