Stimulus-triggered prodrugs

摘要

Set forth herein, inter alia, are compositions and methods for treating diseases with prodrugs. Provided herein are prodrug compositions for inhibiting the function of proteins, compositions and methods for treating diseases associated with oxidative compounds, oxidatively-sensitive prodrugs of inhibitors of metalloproteases. and methods of inhibiting metalloproteases using oxidatively-sensitive prodrugs.

主权项

1. A compound of the formula:wherein,
A is an anticancer drug moiety; R1 is —B(OH)2 or an ROS-reactive boronic ester; and z is an integer from 1 to 5.