Analyte sensors comprising high-boiling point solvents

摘要

Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a high-boiling point solvent, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

主权项

1. A method of fabricating an electrode for use in an analyte sensor, the method comprising:
combining a polymer, enzyme and redox mediator with a high boiling point solvent to produce a sensing layer composition; contacting an electrode with the sensing layer composition to form a sensing layer on a surface of the electrode, wherein the sensing layer composition comprises a high-boiling point solvent at a concentration of 1% to 5% (w/v) of the total formulation of the sensing layer.