发明名称 |
Compositions and methods for treating hepatitis C virus |
摘要 |
Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period. |
申请公布号 |
US8889159(B2) |
申请公布日期 |
2014.11.18 |
申请号 |
US201213686664 |
申请日期 |
2012.11.27 |
申请人 |
Gilead Pharmasset LLC |
发明人 |
Cleary Darryl G.;Reynolds Charles J.;Berrey Miriam Michelle;Hindes Robert G.;Symonds William T.;Ray Adrian S.;Mo Hongmei;Hebner Christy M.;Oliyai Reza;Zia Vahid;Stefanidis Dimitrios;Pakdaman Rowchanak;Casteel Melissa Jean |
分类号 |
A61K47/10;C07H19/04;A61K31/513;A61K31/675;A61K31/4196 |
主分类号 |
A61K47/10 |
代理机构 |
Sheppard Mullin Richter & Hampton LLP |
代理人 |
Sheppard Mullin Richter & Hampton LLP |
主权项 |
1. A pharmaceutical composition comprising:
a) about 25% to about 35% w/w of crystalline GS-7977 having the structureand
b) at least one pharmaceutically acceptable excipient, wherein the crystalline GS-7977 has XRPD 2θ-reflections (°) at about: 6.1 and 12.7. |
地址 |
Foster City CA US |