| 发明名称 |
Immunogenic compositions of <i>Staphylococcus aureus </i>antigens |
| 摘要 |
The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides. |
| 申请公布号 |
US8889145(B2) |
申请公布日期 |
2014.11.18 |
| 申请号 |
US201314032534 |
申请日期 |
2013.09.20 |
| 申请人 |
Wyeth LLC |
发明人 |
Anderson Annaliesa;Pavliak Viliam;Jansen Kathrin Ute;Scully Ingrid Lea;Baker Steven Morris;Nanra Jasdeep Singh;Murphy Ellen;Green Bruce Arthur;Ruppen Mark Edward;Timofeyeva Yekaterina |
| 分类号 |
A61K39/085;A61K39/40;C07K16/12;A61K39/00 |
主分类号 |
A61K39/085 |
| 代理机构 |
|
代理人 |
Molenda Victoria S. |
| 主权项 |
1. An immunogenic composition comprising an isolated Staphylococcus aureus clumping factor A (ClfA) polypeptide, an isolated S. aureus manganese transporter protein C (MntC protein), an isolated S. aureus capsular polysaccharide type 5 conjugated to CRM197, and an isolated S. aureus capsular polysaccharide type 8 conjugated to CRM197, wherein the capsular polysaccharide type 5 has a molecular weight of between 70 and 300 kDa and the capsular polysaccharide type 8 has a molecular weight of between 70 and 150 kDa. |
| 地址 |
New York NY US |
