Compounds and methods for treating bacterial infections

摘要

Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.;

主权项

1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the structure of formula (I):wherein
X is fluorine or chlorine; R1 is selected from the group consisting of hydrogen, phenyl, —C≡N, tetrahydropyranyl, N-methyl-1,2,4-triazolyl, pyrimidinyl, pyridinyl, pyrazinyl, cyclopropyl, —C≡CH, —CH═CH2, and C1-C3 alkyl, which C1-C3 alkyl is optionally substituted with one or more of: —OR10, halogen, —C≡N, —N3, —SO2CH3, —SCH3, —CH═CH2, —CH═NOR11 and phenyl; R2 is selected from the group consisting of hydrogen, —C≡N, pyridinyl, C1-C3 alkyl, which C1-C3 alkyl is optionally substituted with one or more of: halogen, —OR20 and —CH═NOR21; R3 is hydrogen or C1-C3 alkyl; R10 is for each occurrence independently selected from the group consisting of hydrogen, C1-C4 alkyl and —(CH2)2OCH3; and R11, R20 and R21 are for each occurrence independently hydrogen or C1-C4 alkyl.