发明名称 |
INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS |
摘要 |
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells. |
申请公布号 |
WO2014153111(A3) |
申请公布日期 |
2014.11.13 |
申请号 |
WO2014US29111 |
申请日期 |
2014.03.14 |
申请人 |
AMGEN INC. |
发明人 |
GAVIN, MARC A.;KANNAN, GUNASEKARAN;LI, LI;PEARSON, JOSHUA T.;KAROW, MARGARET |
分类号 |
C07K14/55;A61K38/20 |
主分类号 |
C07K14/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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