发明名称 |
Selective exosite inhibition of PAPP-A activity against IGFBP-4 |
摘要 |
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting. |
申请公布号 |
AU2009207645(B2) |
申请公布日期 |
2014.11.13 |
申请号 |
AU20090207645 |
申请日期 |
2009.01.23 |
申请人 |
AARHUS UNIVERSITET |
发明人 |
OXVIG, CLAUS;NIELSEN, CLAUS GYRUP;MIKKELSEN, JAKOB HAUGE |
分类号 |
C07K14/435;A61K38/17;C07K14/47;C07K16/18;C07K16/40;C12N9/64 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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